1.
Indian J Exp Biol
;
1997 Nov; 35(11): 1233-6
Article
in English
| IMSEAR
| ID: sea-57733
ABSTRACT
A new mycotoxin product (NMP) was isolated from the culture of mutated wild strain of P. nigricans which is less toxic and has sterol derivative. NMP (LD50 > 1 g/kg) showed antimicrobial and antineoplastic activities and does not affect the hematological parameters like RBC count and hemoglobin. It maintained normal blood glucose level by increasing the enzyme activity of glucose-6-phosphate dehydrogenase (EC-1.1.1.49; G-6-PDH) by 30%. It also maintained the normal ion balance in the blood of mice. NMP decreased Km value of glucose-6-phosphate dehydrogenase and thus increased substrate affinity of the enzyme. Reduction of toxicity of NMP has been well explained by higher activity of G-6-PDH which is highly specific for production of NADPH.
Subject(s)
Animals , Anthraquinones/pharmacology , Glucosephosphate Dehydrogenase/drug effects , Kinetics , Mice , Mycotoxins/isolation & purification , Penicillium/enzymology
2.
Indian J Exp Biol
;
1987 Jul; 25(7): 458-62
Article
in English
| IMSEAR
| ID: sea-61633